Immuno-Oncology Pipeline

About SYB-010

SYB-010 is a first-in-class immune stimulatory monoclonal antibody targeting a tumor-released immune suppressive molecule, soluble MHC class I chain-related protein (sMIC). In preclinical animal studies, monotherapy with the murine version of SYB-010 effectively reduces tumor size and prolongs overall survival. This innovative antibody also enhances tumor response to immune checkpoint blocking therapies when used in combination, and elicits a positive response even in tumors that failed to respond to these therapies.